Neonatal Encephalopathy (NE) Cluster

25-30% of term born infants with CP are diagnosed with NE (including it’s subset Hypoxic Ischemic Encephalopathy HIE) in the newborn period. There are multiple aetiologies of NE in those that go on to have CP. They include sentinel events during the intrapartum period, birth defects, stroke, intrauterine growth restriction, and a proportion with an unknown aetiology.

Cooling has been a landmark discovery for those with HIE, however, it only prevents cerebral palsy in one in six-nine infants treated. This research cluster focuses on identifying what can be done for those that don’t respond to cooling.

The first activity of IMPACT for CP was to co-sponsor with the National Institute of Child Health and Development (NICHD) a Summit: “Neonatal encephalopathy: Advancing the science and improving outcomes” held, May 8-9, 2013 Washington DC. The Balnaves Foundation were principal supporters of this event.

Current trials can be viewed on the map below.

Clinical Trials


  • Red marker Cooling plus studies
  • Blue marker All other studies

Summary of Cooling plus Studies (Word Doc)
All other studies (Word Doc)


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If you are interested in joining this cluster please contact us.